GHK-Cu Research: Mechanisms, Applications & Protocols

What is GHK-Cu?

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper-binding peptide first identified in human plasma. Its concentration in plasma declines significantly with age, dropping from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60.

Molecular Formula: C14H24N6O4Cu

Molecular Weight: 403.9 g/mol

Sequence: Gly-His-Lys-Cu

Documented Biological Activities

Tissue Remodeling

GHK-Cu has been shown to upregulate and downregulate approximately 4,000 human genes, earning it the classification of a "reset molecule" in gene expression studies.

Extracellular Matrix Regulation

Research demonstrates the peptide's ability to stimulate synthesis of collagen, elastin, and glycosaminoglycans — key components of the extracellular matrix.

Copper Ion Transport

The peptide functions as a copper transporter, delivering this essential trace element to cells in a bioavailable form that doesn't trigger oxidative damage.

Research Applications

- Wound healing studies: Enhanced granulation tissue formation

- Skin research: Increased collagen type I and III production

- Hair follicle research: Dermal papilla cell proliferation

- Anti-inflammatory studies: TGF-beta and TNF-alpha modulation

Stability Considerations

GHK-Cu is notably stable compared to other research peptides. The copper complex exhibits strong resistance to enzymatic degradation, though standard lyophilized storage at -20°C remains recommended for long-term preservation.

This article is for research and educational purposes only. GHK-Cu is sold exclusively for laboratory research use.